[(S)-BINAP] PdBr 2-catalyzed direct synthesis of 2, 3-disubstituted indoles via a tandem reaction between arylamines and α-diketones

…, M Ayala, L Rubio-Perez, M Amézquita-Valencia

文献索引：Cabrera; Sharma; Ayala; Rubio-Perez; Amezquita-Valencia, Manuel Tetrahedron Letters, 2011 , vol. 52, # 50 p. 6758 - 6762

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被引用次数: 13

摘要

A direct PdBr2 (BINAP)-complex catalyzed method has been developed to produce 2, 3- disubstituted indoles by the reaction of arylamines with α-diketones under reductive (H2) conditions. The synthetic methodology involves a tandem reaction of three steps and all the organic intermediates were isolated and characterized, the reduction products in this sequence are chiral and present interesting enantiomeric excess. This report constitutes a ...