Identification of potent and selective inhibitors of PDGF receptor autophosphorylation

…, K Kubo, T Shimizu, R Suzuki, T Yoshino…

文献索引：Furuta, Takayuki; Sakai, Teruyuki; Senga, Terufumi; Osawa, Tatsushi; Kubo, Kazuo; Shimizu, Toshiyuki; Suzuki, Rika; Yoshino, Tetsuya; Endo, Megumi; Miwa, Atsushi Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2186 - 2192

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被引用次数: 53

摘要

We report the structure-activity relationship of quinoline and quinazoline derivatives, which include urea, thiourea, urethane, and acylthiourea groups, as inhibitors of the platelet- derived growth factor (PDGF) receptor autophosphorylation. Our previous studies showed that the quinoline and quinazoline derivatives including urea, thiourea, and carbamate groups were highly potent compounds as the PDGF receptor autophosphorylation ...