Identification of potent and selective inhibitors of PDGF receptor autophosphorylation

…, K Kubo, T Shimizu, R Suzuki, T Yoshino…

Index: Furuta, Takayuki; Sakai, Teruyuki; Senga, Terufumi; Osawa, Tatsushi; Kubo, Kazuo; Shimizu, Toshiyuki; Suzuki, Rika; Yoshino, Tetsuya; Endo, Megumi; Miwa, Atsushi Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2186 - 2192

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Citation Number: 53

Abstract

We report the structure-activity relationship of quinoline and quinazoline derivatives, which include urea, thiourea, urethane, and acylthiourea groups, as inhibitors of the platelet- derived growth factor (PDGF) receptor autophosphorylation. Our previous studies showed that the quinoline and quinazoline derivatives including urea, thiourea, and carbamate groups were highly potent compounds as the PDGF receptor autophosphorylation ...