Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1
PH Bernardo, T Sivaraman, KF Wan, J Xu…
文献索引：Bernardo, Paul H.; Sivaraman, Thirunavukkarasu; Wan, Kah-Fei; Xu, Jin; Krishnamoorthy, Janarthanan; Sons, Chun Meng; Tian, Liming; Chin, Jasmine S. F.; Lim, Diane S. W.; Mok, Henry Y. K.; Yu, Victor C.; Tong, Joo Chuan; Chai, Christina L. L. Journal of Medicinal Chemistry, 2010 , vol. 53, # 5 p. 2314 - 2318
The screening of a small focused library of rhodanine derivatives as inhibitors of Bcl-2 proteins led to the discovery of two structurally related compounds with different binding profiles against the Bcl-XL and the Mcl-1 proteins. Subsequent NMR studies with mutant proteins and in silico docking studies provide a possible rationale for the observed specificity.
