Tetrahedron letters

The expedient access to bromo-pyridine carbaldehyde scaffolds using gem-dibromomethyl intermediates

AB Mandal, JK Augustine, A Quattropani, A Bombrun

文献索引：Mandal, Ashis Baran; Augustine, John Kallikat; Quattropani, Anna; Bombrun, Agnes Tetrahedron Letters, 2005 , vol. 46, # 36 p. 6033 - 6036

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被引用次数: 17

摘要

A simple, efficient, and general two-step synthesis to bromo-pyridine carbaldehyde scaffolds is described. This direct route involves sequential reactions employing the dibromination of bromo-picolines followed by hydrolysis using an aqueous solution of calcium carbonate. Bromo-pyridine carbaldehyde scaffolds were obtained in good overall yield. Bromo- dibromomethyl-pyridine intermediates have been isolated and characterized.