1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesis

MS Bernatowicz, Y Wu…

文献索引：Bernatowicz, Michael S.; Wu, Youling; Matsueda, Gary R. Journal of Organic Chemistry, 1992 , vol. 57, # 8 p. 2497 - 2502

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被引用次数: 301

摘要

Introduction The possibility of preparing arginine-containing peptides by guanylation of the 6- amino groups of the appropriate ornithine-containing precursors has long been recognized. Such a strategy is attractive for its potential to eliminate the many problems associated with the use of conventionally protected arginine starting materials in peptide synthesis. 2 It is also attractive because it allows for the