Conformations, conformational preferences, and conformational exchange of N′-substituted N-acylguanidines: intermolecular interactions hold the key

…, P Igel, A Buschauer, RM Gschwind

文献索引：Kleinmaier, Roland; Keller, Max; Igel, Patrick; Buschauer, Armin; Gschwind, Ruth M. Journal of the American Chemical Society, 2010 , vol. 132, # 32 p. 11223 - 11233

全文：HTML全文

被引用次数: 13

摘要

Guanidine and acylguanidine groups are crucial structural features of numerous biologically active compounds. Depending on the biological target, acylguanidines may be considered as considerably less basic bioisosteres of guanidines with improved pharmacokinetics and pharmacodynamics, as recently reported for N′-monoalkylated N-acylguanidines as ligands of G-protein-coupled receptors (GPCRs). The molecular basis for enhanced ...