Abstract Some potentially biologically active 6-substituted purine derivatives have been synthesized from simple organic reagents. The reaction of urea with ethyl cyanoacetate gave 6-aminopyrimidine-2, 4-dione which was converted in two steps into purine derivative, xanthine. The latter was treated with formamide at 200° C to obtain hypoxanthine. The chlorination of hypoxanthine with POCl 3 gave 6-chloropurine which was converted into 6- ...
