Russian journal of organic chemistry

Synthesis of purine antiviral agents, hypoxanthine and 6-mercaptopurine

R Sariri, G Khalili

Index: Sariri; Khalili Russian Journal of Organic Chemistry, 2002 , vol. 38, # 7 p. 1053 - 1055

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Citation Number: 13

Abstract

Abstract Some potentially biologically active 6-substituted purine derivatives have been synthesized from simple organic reagents. The reaction of urea with ethyl cyanoacetate gave 6-aminopyrimidine-2, 4-dione which was converted in two steps into purine derivative, xanthine. The latter was treated with formamide at 200° C to obtain hypoxanthine. The chlorination of hypoxanthine with POCl 3 gave 6-chloropurine which was converted into 6- ...