A Metal??Free Oxidative Esterification of the Benzyl C H Bond

J Feng, S Liang, SY Chen, J Zhang…

文献索引：Feng, Jie; Liang, Shuai; Chen, Shan-Yong; Zhang, Ji; Fu, Song-Sen; Yu, Xiao-Qi Advanced Synthesis and Catalysis, 2012 , vol. 354, # 7 p. 1287 - 1292

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被引用次数: 98

摘要

Abstract An efficient metal-free oxidative esterification of benzyl C [BOND] H bonds was developed. Using tetrabutylammonium iodide as catalyst and tert-butyl hydroperoxide as co- oxidant, benzylic substrates could react smoothly with various carboxylic acids to give the esters with good to excellent yields. The method was also suitable for the O-protection of N- Boc amino acids. The reaction mechanism was primarily investigated and a radical ...