Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

TP Petersen, AF Larsen, A Ritzén…

文献索引：Petersen, Trine P.; Larsen, Anders Foller; Ritzen, Andreas; Ulven, Trond Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4190 - 4195

全文：HTML全文

被引用次数: 16

摘要

Aryldimethylamines can be prepared by nucleophilic aromatic substitution (S N Ar) of aryl or heteroaryl halides with dimethylamine. However, because of the volatile nature of this reagent and the high temperatures or long reaction times often required,(1) outgassing from open flask reactors or pressure build-up under sealed-tube conditions can be problematic. Rather than using a premade solution, dimethylamine can be produced in situ from thermal ...