Tetrahedron

A mild, catalyst-free synthesis of 2-aminopyridines

B Poola, W Choung, MH Nantz

文献索引：Poola, Bhaskar; Choung, Wonken; Nantz, Michael H. Tetrahedron, 2008 , vol. 64, # 48 p. 10798 - 10801

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被引用次数: 11

摘要

Alkylation of 2-mercaptopyridine with 1, 2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.