Highly regioselective functionalization of aliphatic carbon-hydrogen bonds with a perbromohomoscorpionate copper (I) catalyst

…, MM Díaz-Requejo, TR Belderraín…

文献索引：Caballero, Ana; Diaz-Requejo, M. Mar; Belderrain, Tomas R.; Nicasio, M. Carmen; Trofimenko, Swiatoslaw; Perez, Pedro J. Journal of the American Chemical Society, 2003 , vol. 125, # 6 p. 1446 - 1447

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被引用次数: 93

摘要

The expected enhancement of the catalytic activity with 1 was demonstrated upon reacting EDA and cyclohexane (eq 2): ethyl 2-cyclohexyl acetate was obtained in 90% yield (based in EDA, [Cu]:[EDA]:[C 6 H 12 ], 1:20:1000). But, as mentioned above, acyclic substrates present more interest from the functionalization point of view. A series of experiments 16 have been carried out with such molecules; the results are summarized in Table 1. The chemoselectivity ...