The First Well??Defined Silver (I)??Complex??Catalyzed Cycloaddition of Azides onto Terminal Alkynes at Room Temperature

J McNulty, K Keskar, R Vemula

文献索引：McNulty, James; Keskar, Kunal; Vemula, Ramesh Chemistry - A European Journal, 2011 , vol. 17, # 52 p. 14727 - 14730

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被引用次数: 64

摘要

The copper (I)-catalyzed Huisgen dipolar cycloaddition of terminal alkynes 1 with azides 2 [1] to yield 1, 4-and 1, 4, 5-substituted 1, 2, 3-triazoles 3 (azide–alkyne cycloaddition; AAC reaction) has been transformed in recent years, since its description as the prototype “click” reaction,[2] to become a general process with applications in diverse areas ranging from functional materials [3] to biological chemistry.[4, 5] The generally accepted mechanism ...