The copper-catalyzed azide–alkyne cycloaddition (CuAAC), also known as a “click reaction”, has become one of the most important reactions for the preparation of 1,2,3-triazoles. 1 This important reaction has found a wide range of applications in organic synthesis, bio- and medicinal chemistry, and materials science. 2 Most AAC protocols call for a homogeneous Cu(I) source – either by direct addition of a Cu(I) salt, or by in situ reduction of Cu(II) by sodium ...
