Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2, 4-hexadienoic acid hydroxyamides

CM Marson, P Savy, AS Rioja…

文献索引：Durrant, Graham; Green, Richard H.; Lambeth, Paul F.; Lester, Michael G.; Taylor, Nigel R. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2211 - 2214

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被引用次数: 16

摘要

... figure Scheme 3 a. a Reagents: (a) NaOMe, MeOH, THF; (b) H 2 , Pd/C; (c) 37% aqueous HCHO, NaBH 3 CN, ZnCl 2 , MeOH; (d) LiAlH 4 , THF; (e) pyridine−SO 3 , Et 3 N, DMSO; (f) Ph 3 P CHCO 2 Et, CH 2 Cl 2 ; (g) 50% aqueous NH 2 OH, 1 M KOH in MeOH, THF. ...