2-Aryl-3H-indol-3-ones: Synthesis, electrochemical behaviour and antiplasmodial activities

…, A Valentin, PL Fabre, K Reybier, F Nepveu

文献索引：Najahi, Ennaji; Valentin, Alexis; Fabre, Paul-Louis; Reybier, Karine; Nepveu, Francoise European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 269 - 274

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被引用次数: 7

摘要

Abstract The synthesis of indolone derivatives and their antiplasmodial activity in vitro against Plasmodium falciparum at the blood stage are described. The 2-aryl-3H-indol-3- ones were synthesized via deoxygenation of indolone-N-oxides. Electrochemical behaviour, antiplasmodial activity and cytotoxicity on human tumor cell lines were compared to those of indolone-N-oxides. The antiplasmodial IC 50 (concentrations at 50% inhibition) of these ...