A one-step synthesis of 2-(2-pyridyl)-3H-indol-3-one N-oxide: is it an efficient spin trap for hydroxyl radical?

…, P Casara, M Spedding, HJ Halpern

文献索引：Rosen, Gerald M.; Tsai, Pei; Barth, Eugene D.; Dorey, Gilbert; Casara, Patrick; Spedding, Michael; Halpern, Howard J. Journal of Organic Chemistry, 2000 , vol. 65, # 14 p. 4460 - 4463

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被引用次数: 45

摘要

The field of free radicals in biology has its origins in a series of publications in the late 1960s in which the secretion of superoxide (O2•-) during the enzymic cycling of xanthine oxidase was first described. 1 Soon thereafter, a Cu/Zn-containing enzyme was found to disproportionate this free radical into O2 and H2O2. 2 This enzyme, which became known as superoxide dismutase (SOD), has played a pivotal role in defining the ubiquitous ...