New optimized piperamide analogues with potent in vivo hypotensive properties

C de Mattos Duarte, H Verli, JX de Araújo-Júnior…

文献索引：Duarte, Carolina De Mattos; Verli, Hugo; Araujo-Junior, Joao Xavier De; Medeiros, Isac Almeida De; Barreiro, Eliezer J.; Fraga, Carlos Alberto Manssour European Journal of Pharmaceutical Sciences, 2004 , vol. 23, # 4-5 p. 363 - 369

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被引用次数: 23

摘要

We describe herein the structural optimization of new piperamide analogues, designed from two natural prototypes, piperine 1 and piperdardine 2, obtained from Piper tuberculatum Jacq.(Piperaceae). Molecular modeling studies using semiempirical AM1 method were made in order to establish rational modifications to optimize them by molecular simplification. The targeted compounds (10) and (11) were respectively obtained using ...