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Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects

GS Hamilton, YQ Wu, DC Limburg…

文献索引:Journal of Medicinal Chemistry, , vol. 45, # 16 p. 3549 - 3557

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被引用次数: 38

摘要

... Journal of Medicinal Chemistry. ... Chemistry. Scheme 1 shows the general synthetic route for the compounds. Reaction of proline methyl ester or methyl pipecolinate with methyl chlorooxoacetate provided the oxamate as the key intermediate. ...