Development of a polymer bound Wittig reaction and use in multi-step organic synthesis for the overall conversion of alcohols to β-hydroxyamines

MH Bolli, SV Ley

文献索引：Bolli, Martin H.; Ley, Steven V. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 15 p. 2243 - 2246

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被引用次数: 74

摘要

An efficient combinatorial access to β-hydroxyamines suitable for automation is achieved by the mild oxidation of alcohols to aldehydes by polymer supported perruthenate (PSP), the subsequent clean olefination of the obtained aldehydes by polymer supported Wittig reagents followed by the epoxidation of the olefins by dimethyldioxirane (DMDO), and the final aminolysis of the epoxides with various amines is described.