Development of a polymer bound Wittig reaction and use in multi-step organic synthesis for the overall conversion of alcohols to β-hydroxyamines

MH Bolli, SV Ley

Index: Bolli, Martin H.; Ley, Steven V. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 15 p. 2243 - 2246

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Citation Number: 74

Abstract

An efficient combinatorial access to β-hydroxyamines suitable for automation is achieved by the mild oxidation of alcohols to aldehydes by polymer supported perruthenate (PSP), the subsequent clean olefination of the obtained aldehydes by polymer supported Wittig reagents followed by the epoxidation of the olefins by dimethyldioxirane (DMDO), and the final aminolysis of the epoxides with various amines is described.