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Development and a practical synthesis of the JAK2 inhibitor LY2784544

D Mitchell, KP Cole, PM Pollock…

文献索引:Organic Process Research and Development, , vol. 16, # 1 p. 70 - 81

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被引用次数: 18

摘要

... many intermediates can be expected to be sparingly soluble in common organic solvents, which ... In addition, we wanted to investigate the overall solvent selection, and process mass intensity ... A 450-g demonstration of this procedure was performed, and provided a 92% isolated ...