Development and a practical synthesis of the JAK2 inhibitor LY2784544

D Mitchell, KP Cole, PM Pollock…

Index: Organic Process Research and Development, , vol. 16, # 1 p. 70 - 81

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Citation Number: 18

Abstract

... many intermediates can be expected to be sparingly soluble in common organic solvents, which ... In addition, we wanted to investigate the overall solvent selection, and process mass intensity ... A 450-g demonstration of this procedure was performed, and provided a 92% isolated ...