Formation of N-acetyl-p-benzoquinone imine, the well-known toxic metabolite of acetaminophen, by the reaction of acetaminophen with nitrite under model stomach …
T Ohta, H Oribe, M Ide, S Takitani
文献索引：Ohta; Oribe; Ide; Takitani Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4634 - 4637
The main reaction product of acetaminophen (4mM) with nitrite (1mM) under model stomach conditions was identified as p-benzoquinone. HPLC analysis of the reaction mixture with an electrochemical detector revealed the presence of N-acetyl-p-benzoquinone imine, the toxic
