N-乙酰苯醌亚胺结构式
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常用名 | N-乙酰苯醌亚胺 | 英文名 | N-Acetylimidoquinone |
|---|---|---|---|---|
| CAS号 | 50700-49-7 | 分子量 | 149.147 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 255.6±43.0 °C at 760 mmHg | |
| 分子式 | C8H7NO2 | 熔点 | 74-75ºC | |
| MSDS | 中文版 美版 | 闪点 | 101.6±33.5 °C |
N-乙酰苯醌亚胺用途NAPQI是对乙酰氨基酚的有毒代谢产物。NAPQI也是维生素K循环中酶的抑制剂。NAPQI通过谷胱甘肽(GSH)快速解毒,但在缺乏GSH的情况下,过量的NAPQI与蛋白质中的半胱氨酸残基反应,导致肝细胞死亡和毒性[1][2]。 |
| 中文名 | N-乙酰苯醌亚胺 |
|---|---|
| 英文名 | N-acetyl-1,4-benzoquinone imine |
| 英文别名 | 更多 |
| 描述 | NAPQI是对乙酰氨基酚的有毒代谢产物。NAPQI也是维生素K循环中酶的抑制剂。NAPQI通过谷胱甘肽(GSH)快速解毒,但在缺乏GSH的情况下,过量的NAPQI与蛋白质中的半胱氨酸残基反应,导致肝细胞死亡和毒性[1][2]。 |
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| 相关类别 | |
| 靶点 |
Human Endogenous Metabolite |
| 参考文献 |
| 密度 | 1.1±0.1 g/cm3 |
|---|---|
| 沸点 | 255.6±43.0 °C at 760 mmHg |
| 熔点 | 74-75ºC |
| 分子式 | C8H7NO2 |
| 分子量 | 149.147 |
| 闪点 | 101.6±33.5 °C |
| 精确质量 | 149.047684 |
| PSA | 46.50000 |
| LogP | 0.38 |
| 外观性状 | 黄色结晶固体 |
| 蒸汽压 | 0.0±0.5 mmHg at 25°C |
| 折射率 | 1.545 |
| 储存条件 | -20°C |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
| RTECS号 | AC6960000 |
| 海关编码 | 2924299090 |
| 海关编码 | 2924299090 |
|---|---|
| 中文概述 | 2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0% |
| 申报要素 | 品名, 成分含量, 用途, 包装 |
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury.
Hepatology 61(1) , 326-36, (2015) Acetaminophen (APAP) overdose is a frequent cause of drug-induced liver injury and the most frequent cause of acute liver failure in the Western world. Previous studies with mouse models have revealed... |
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Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases.
Int. J. Clin. Pharmacol. Ther. 45(9) , 496-503, (2007) Paracetamol (PCM) is frequently used in pediatric patients with neoplastic disease. It is metabolized mainly by conjugation, but at therapeutic concentrations, a small fraction of the drug undergoes o... |
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Use of a systems model of drug-induced liver injury (DILIsym®) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice
Toxicol. Lett. 226(2) , 163-72, (2014) Acetaminophen (APAP) has been used as a probe drug to investigate drug-induced liver injury (DILI). In mice, 3′-hydroxyacetanilide (AMAP), a less-toxic isomer of APAP, has also been studied as a negat... |
| Acetimidoquinone |
| N-Acetyl-1,4-benzoquinone imine |
| N-Acetyl-p-benzoquinonimine |
| p-benzoquinonimine, N-acetyl- |
| N-(4-Oxo-2,5-cyclohexadien-1-ylidene)acetamide |
| N-Acetyl-P-benzoquinoneimine |
| N-Acetyl-4-benzoquinone Imine |
| N-acetyl-4-benzoquinoneimine |
| Acetamide, N-(4-oxo-2,5-cyclohexadien-1-ylidene)- |
| N-(4-Oxocyclohexa-2,5-dien-1-ylidene)acetamide |
| NAPQI |
| N-(4-Oxo-1-cyclohexa-2,5-dienylidene)acetamide,N-Acetyl-p-benzo-quinoneimine,NAPQI |
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