New class of potent antitumor acylhydrazone derivatives containing furan

…, Y Li, Y Ling, J Huang, J Cui, R Wang, X Yang

文献索引：Cui, Zining; Li, Ying; Ling, Yun; Huang, Juan; Cui, Jingrong; Wang, Ruiqing; Yang, Xinling European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5576 - 5584

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被引用次数: 76

摘要

A pair of chemical isomeric structures of N-acylhydrazone compounds I and II were designed and synthesized. The reaction was carried out with high diastereoselectivity to obtain one configurational isomer in excellent yields. The exact configuration and conformation of IIa and IIe were confirmed by the X-ray single crystal diffraction. The antitumor bioassay revealed that some compounds exhibited excellent activity against the ...