Metalloform-selective inhibition: synthesis and structure–activity analysis of Mn (II)-form-selective inhibitors of Escherichia coli methionine aminopeptidase

QQ Huang, M Huang, FJ Nan, QZ Ye

文献索引：Huang, Qing-Qing; Huang, Min; Nan, Fa-Jun; Ye, Qi-Zhuang Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 24 p. 5386 - 5391

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被引用次数: 27

摘要

Methionine aminopeptidase (MetAP) is a promising target for development of novel antibacterial, antifungal and anticancer agents. However, its physiologically relevant metal ion remains to be defined, and its inhibitors need to inhibit the in vivo metalloform. Based on the Mn (II)-form-selective inhibitors discovered by high throughput screening as leads, a series of analogs of 5-phenylfuran-2-carboxylic acid was prepared and subsequently ...