Retinobenzoic acids. 3. Structure-activity relationships of retinoidal azobenzene-4-carboxylic acids and stilbene-4-carboxylic acids

…, K Namikawa, E Kawachi, Y Hashimoto…

文献索引：Kagechika; Himi; Namikawa; Kawachi; Hashimoto; Shudo Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1098 - 1108

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被引用次数: 56

摘要

Alkyl-substituted azobenzene-4-carboxylic acids are potent differentiation inducers of human promyelocytic leukemia cell line HL-60 to mature granulocytes. Their structure- activity relationships are very similar to those of other retinoidal benzoic acids which are generally represented by 4 and named retinobenzoic acids. The structure-activity relationships of azobenzenecarboxylic acids can also be applied to the known retinoid ...