An expeditious and convenient one pot synthesis of 2, 5-disubstituted-1, 3, 4-oxadiazoles

SH Mashraqui, SG Ghadigaonkar…

文献索引：Mashraqui, Sabir H.; Ghadigaonkar, Shailesh G.; Kenny, Rajesh S. Synthetic Communications, 2003 , vol. 33, # 14 p. 2541 - 2545

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被引用次数: 56

摘要

Abstract A convenient, one pot procedure is reported for the synthesis of a variety of 2, 5- disubstituted-1, 3, 4-oxadiazoles by condensing mono-arylhydrazides with acid chlorides in HMPA solvent under the microwave heating. The yields are good to excellent, the process is rapid and does not need any added acid catalyst or dehydrating reagent.