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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis and methemoglobinemia-inducing properties of benzocaine isosteres designed as humane rodenticides

D Conole, TM Beck, M Jay-Smith, MD Tingle…

文献索引：Conole, Daniel; Beck, Thorsten M.; Jay-Smith, Morgan; Tingle, Malcolm D.; Eason, Charles T.; Brimble, Margaret A.; Rennison, David Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2220 - 2235

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被引用次数: 9

摘要

Abstract A number of isosteres (oxadiazoles, thiadiazoles, tetrazoles and diazines) of benzocaine were prepared and evaluated for their capacity to induce methemoglobinemia— with a view to their possible application as humane pest control agents. It was found that an optimal lipophilicity for the formation of methemoglobin (metHb) in vitro existed within each series, with 1, 2, 4-oxadiazole 3 (metHb%= 61.0±3.6) and 1, 3, 4-oxadiazole 10 (metHb% ...

3-phenyl-5-(4'-nitrophenyl)-1,2,4-oxadiazole结构式

3-phenyl-5-(4'-...

~82%

4-(3-phenyl-1,2,4-oxadiazol-5-yl)aniline结构式

4-(3-phenyl-1,2...

苄胺肟结构式

~%

4-(3-phenyl-1,2,4-oxadiazol-5-yl)aniline结构式

4-(3-phenyl-1,2...

苯甲腈结构式

~%

4-(3-phenyl-1,2,4-oxadiazol-5-yl)aniline结构式

4-(3-phenyl-1,2...

苯甲酰氯结构式

4-硝基苯肼结构式

~76%

Benzoic acid, 4-nitro-,2-benzoylhydrazide结构式

Benzoic acid, 4...

4'-(4,4,5,5-四甲基-1,3,2-二杂氧戊硼烷-2-基)乙酰苯胺结构式

4'-(4,4,5,5-四甲基...

~%

4-(4-氨基苯基)嘧啶结构式

4-(4-氨基苯基)嘧啶

N-(4-(6-chloropyrimidin-4-yl)phenyl)acetamide结构式

N-(4-(6-chlorop...

~%

4-(4-氨基苯基)嘧啶结构式

4-(4-氨基苯基)嘧啶

对硝基苯甲酰氯结构式

对硝基苯甲酰氯

~%

5-甲基-2-[4-(硝基苯基)-1,3,4-恶二唑结构式

5-甲基-2-[4-(硝基苯基...

对硝基苯甲酰氯结构式

对硝基苯甲酰氯

~%

4-硝基硫代苯甲酰胺结构式

4-硝基硫代苯甲酰胺

4'-(4,4,5,5-四甲基-1,3,2-二杂氧戊硼烷-2-基)乙酰苯胺结构式

4'-(4,4,5,5-四甲基...

~%

4-(嘧啶-5-基)苯胺结构式

4-(嘧啶-5-基)苯胺

对硝基苯甲酰氯结构式

对硝基苯甲酰氯

~%

2-(4-nitrophenyl)-5-phenyl-[1,3,4]oxadiazole结构式

2-(4-nitropheny...

对硝基苯甲酰氯结构式

对硝基苯甲酰氯

~56%

4-硝基苯肼结构式

丁酸酐结构式

对硝基苯胺结构式

对硝基苯胺

~80%

N-(4-nitrophenyl)butanamide结构式

N-(4-nitropheny...

N-(4-(pyridin-4-yl)phenyl)acetamide结构式

N-(4-(pyridin-4...

~91%

4-(吡啶-4-基)苯胺结构式

4-(吡啶-4-基)苯胺

5-甲基-2-[4-(硝基苯基)-1,3,4-恶二唑结构式

5-甲基-2-[4-(硝基苯基...

~53%

4-(5-甲基-1,3,4-噁二唑-2-基)苯胺结构式

4-(5-甲基-1,3,4-噁...

对硝基苯甲酰氯结构式

对硝基苯甲酰氯

~%

4-(5-甲基-1,3,4-噁二唑-2-基)苯胺结构式

4-(5-甲基-1,3,4-噁...

4-硝基苯肼结构式

~%

4-(5-甲基-1,3,4-噁二唑-2-基)苯胺结构式

4-(5-甲基-1,3,4-噁...

1-Acetyl-2-(4-nitrobenzoyl)hydrazine结构式

1-Acetyl-2-(4-n...

~%

4-(5-甲基-1,3,4-噁二唑-2-基)苯胺结构式

4-(5-甲基-1,3,4-噁...

4-硝基苯肼结构式

乙酰氯结构式

~30%

1-Acetyl-2-(4-nitrobenzoyl)hydrazine结构式

1-Acetyl-2-(4-n...

对硝基苯甲酰氯结构式

对硝基苯甲酰氯

~%

1-Acetyl-2-(4-nitrobenzoyl)hydrazine结构式

1-Acetyl-2-(4-n...