Tetrahedron Letters

NBS or DEAD as effective reagents in α-thiocyanation of enolizable ketones with ammonium thiocyanate

BVS Reddy, SMS Reddy, C Madan

文献索引：Reddy, B.V. Subba; Reddy, S. Madhu Sudana; Madan, Ch. Tetrahedron Letters, 2011 , vol. 52, # 13 p. 1432 - 1435

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被引用次数: 15

摘要

Ketones possessing α-hydrogen undergo smooth thiocyanation with ammonium thiocyanate in the presence of N-bromosuccinimide (NBS) at room temperature in acetonitrile under neutral conditions to produce the corresponding α-ketothiocyanates in excellent yields with high selectivity. The use of NBS makes this procedure simple, convenient and cost effective. In addition, diethyl azodicarboxylate (DEAD) was also found to promote this reaction ...