Synthesis and leukemia cell growth inhibition of a series of 1, 3-dithiazolylbenzene derivatives

IM Lagoja, K Nauwelaerts, C Bal-Mahieu…

文献索引：Lagoja, Irene M.; Nauwelaerts, Koen; Bal-Mahieu, Christine; Pasqualini, Michela; Bailly, Christian; Herdewijn, Piet Collection of Czechoslovak Chemical Communications, 2004 , vol. 69, # 7 p. 1491 - 1498

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摘要

Abstract By a slightly modified Hantzsch thiazole synthesis either 1, 3-bis [(thiazol-2-yl) amino] benzene derivatives 2 or 1, 3-bis [2-iminothiazol-3 (2H)-yl] benzene derivatives 3 were exclusively obtained. The compounds can be distinguished by NMR spectroscopy. Compounds 2a-2d and 3a-3d were evaluated for their potential antitumor activity, DNA interaction, and for their activity against DNA and RNA viruses and against HIV-1 and HIV- ...