Synthesis and in vitro cytotoxic evaluation of N-alkylbromo and N-alkylphthalimido-isatins

…, V Kumar, PMS Bedi, MP Mahajan, I Sehar…

文献索引：Singh, Pardeep; Kaur, Sharanjeet; Kumar, Vipan; Bedi; Mahajan; Sehar, Irum; Pal, Harish Chandra; Saxena, Ajit Kumar Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 3017 - 3020

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被引用次数: 27

摘要

Abstract The manuscript pertains to the synthesis and in vitro cytotoxic evaluation of a series of N-alkylbromo and N-alkylphthalimido-isatins against four different human cancer cell lines namely Colon: HCT-15; Liver: Hep-2; Lung: A-549 and Leukemia: THP-1 at 10 and 100 μM concentrations. The active compounds based on preliminary studies were evaluated for their IC 50 value against six cell lines viz. Colo-205, HCT-15 (Colon), THP-1 (Leukemia), A-549 ...