Tetrahedron letters

Short-step synthesis of droloxifene via the three-component coupling reaction among aromatic aldehyde, cinnamyltrimethylsilane, and β-chlorophenetole

Y Sano, I Shiina

文献索引：Sano, Yoshiyuki; Shiina, Isamu Tetrahedron Letters, 2006 , vol. 47, # 10 p. 1631 - 1635

全文：HTML全文

被引用次数: 7

摘要

A short-step route for the preparation of droloxifene has been established via the novel three- component coupling reaction among 3-pivaloyloxybenzaldehyde, cinnamyltrimethylsilane, and β-chlorophenetole, the successive installation of the side-chain part, and the base- induced migration of the double bond. The present synthesis of tetra-substituted ethylene moieties is a widely applicable strategy for producing a variety of SERMs (selective ...