Studies on novel 2-imidazolidinones and tetrahydropyrimidin-2 (1H)-ones as potential TACE inhibitors: design, synthesis, molecular modeling, and preliminary …

S DasGupta, PR Murumkar, R Giridhar…

文献索引：DasGupta, Shirshendu; Murumkar, Prashant R.; Giridhar, Rajani; Yadav, Mange Ram Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3604 - 3617

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被引用次数: 25

摘要

Compounds belonging to the class of 2-imidazolidinones and tetrahydropyrimidin-2 (1H)- ones were synthesized and evaluated for their TACE inhibitory activity. Most of the compounds showed very good TACE inhibitory activity. Docking study clearly indicates importance of the P1′ group of the inhibitor for the TACE inhibitory activity. This work proves that these two classes of molecules could be used as potential leads for the ...