Chemical and Pharmaceutical Bulletin

One-pot preparation of oxazol-5 (4h)-ones from amino acids in aqueous solvents

H Fujita, M Kunishima

文献索引：Fujita, Hikaru; Kunishima, Munetaka Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 7 p. 907 - 912

全文：HTML全文

被引用次数: 3

摘要

A method for one-pot synthesis of oxazol-5 (4H)-ones has been developed using 4-(4, 6- dimethoxy-1, 3, 5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM), which is available for the activation of carboxylic acids in an aqueous solvent. The oxazolones were prepared by the N-acylation of amino acids with carboxylic acids and the subsequent cyclodehydration of the resulting N-acylamino acids by the addition of N, N-diethylaniline. ...