Properties and Reactions of Substituted 1, 2??Thiazetidine 1, 1??Dioxides: Chiral Mono??and Bicyclic 1, 2??Thiazetidine 1, 1??Dioxides from α??Amino Acids

…, A Breckel, BA Thaher, N Manicone…

文献索引：Meinzer, Alexandra; Breckel, Andrea; Thaher, Bassam Abu; Manicone, Nico; Otto, Hans-Hartwig Helvetica Chimica Acta, 2004 , vol. 87, # 1 p. 90 - 105

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被引用次数: 46

摘要

Abstract New chiral mono-and bicyclic β-sultams, valuable building blocks for drug synthesis, have been prepared from L-Ala, L-Val, L-Leu, L-Ile, L-Phe, L-Cys, L-Ser, L-Thr, and D-penicillamine by transformation of the COOH group into a methylsulfonyl chloride function, followed by cyclization under basic conditions. Selected properties, derivatives, and reactions of the β-sultams are described.