Tetrahedron letters

Chelation-controlled cyclization of β-ketoester-substituted and β-ketoamide-substituted allylsilanes.

GA Molander, SW Andrews

文献索引：Molander, Gary A.; Andrews, Steven W. Tetrahedron Letters, 1986 , vol. 27, # 27 p. 3115 - 3118

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被引用次数: 18

摘要

Abstract The first examples of Lewis acid-catalyzed chelation-controlled cyclization reactions are reported. Titanium tetrachloride-initiated cyclization of β-ketoester and β-ketoamide- substituted allylsilanes proceeds in isolated yields of 65–88%, providing a single diastereomeric product in each case.