Name | 6-chloro-7H-purine |
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Synonyms |
7H-Purine, 6-chloro-
5-chloropurine 1H-purine, 6-chloro- 1H-6-chloropurine Purine,6-chloro MFCD00075825 1H-Purine,6-chloro 6-Chloropurine 6-Chloro-1H-purine chloropurine,6 EINECS 201-745-6 6-Chlorpurine 6-CP 6-CHLORO-9H-PURINE |
Description | 6-Chloropurine is a building block in chemical synthesis. Intermediate in the preparation of 9-alkylpurines and 6-rnercaptopurine. Antitumor activities[1]. |
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Related Catalog | |
In Vivo | 6-Chloropurine to S-(6-punnyl)glutathione and further metabolism of S-(6-punnyl)glutathione to 6-mercaptopunne may be involved in the mechanism of the 6-Chloropurine-induced antitumor activity[1]. 6-chloropurine and azaserine have been shown to have synergic antitumor properties in a variety of mouse neoplasms when administered simultaneously[1]. |
References |
Density | 1.7±0.1 g/cm3 |
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Boiling Point | 449.6±25.0 °C at 760 mmHg |
Melting Point | >300 °C (dec.)(lit.) |
Molecular Formula | C5H3ClN4 |
Molecular Weight | 154.557 |
Flash Point | 258.2±8.8 °C |
Exact Mass | 154.004623 |
PSA | 54.46000 |
LogP | 0.13 |
Vapour Pressure | 0.0±1.1 mmHg at 25°C |
Index of Refraction | 1.740 |
Storage condition | 2-8°C |
Water Solubility | 5 g/L |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xn:Harmful |
Risk Phrases | R22;R36/37/38 |
Safety Phrases | S26-S36-S36/37/39 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | UO7520000 |
HS Code | 2933990090 |
~86% 87-42-3 |
Literature: Organic and Biomolecular Chemistry, , vol. 2, # 5 p. 665 - 670 |
~92% 87-42-3 |
Literature: Tetrahedron Letters, , vol. 48, # 32 p. 5589 - 5592 |
~0% 87-42-3 |
Literature: Nucleosides, Nucleotides and Nucleic Acids, , vol. 26, # 10-12 p. 1431 - 1434 |
~% 87-42-3 |
Literature: Nucleosides, Nucleotides and Nucleic Acids, , vol. 24, # 10-12 p. 1707 - 1727 |
~% 87-42-3 |
Literature: Russian Journal of Organic Chemistry, , vol. 38, # 7 p. 1053 - 1055 |
~% 87-42-3 |
Literature: Tetrahedron, , vol. 43, # 6 p. 1133 - 1140 |
~% 87-42-3 |
Literature: Tetrahedron, , vol. 43, # 6 p. 1133 - 1140 |
Precursor 5 | |
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DownStream 10 | |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |