704888-90-4

704888-90-4 structure

Name: ARP-100
Chemical Name: N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide
CAS Number: 704888-90-4
Molecular Formula: C₁₇H₂₀N₂O₅S
Molecular Weight: 364.416
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2018-12-26 14:28:23
Modify Date: 2024-04-03 14:06:36
ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM)[1][2].

Name	N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide
Synonyms	MMP-2 Inhibitor III ARP 100 N-(4-Biphenylylsulfonyl)-N-hydroxy-N-isopropoxyglycinamide N-(biphenyl-4-ylsulfonyl)-N-hydroxy-N-(propan-2-yloxy)glycinamide Acetamide, 2-[([1,1'-biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-

Description	ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP-2:12 nM (IC50) MMP-9:0.2 μM (IC50) MMP-3:4.5 μM (IC50) MMP-1:>50 μM (IC50) MMP-7:>50 μM (IC50)
In Vitro	ARP-100 (50 nM) shows a significant reduction in the total number of invasive elongations[1].
References	[1]. Rossello A, et al. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorg Med Chem. 2004 May 1;12(9):2441-50. [2]. Tuccinardi T, et al. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides. Bioorg Med Chem. 2006 Jun 15;14(12):4260-76.

HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%