- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Propargyl-Tos
- Price: ￥238.0/1g ￥98.0/250mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Propargyl-Tos
- Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 3-Butynyl 4-methylbenzenesulfonate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
23418-85-1
23418-85-1 structure
- Name: Propargyl-Tos
- Chemical Name: but-3-ynyl 4-methylbenzenesulfonate
- CAS Number: 23418-85-1
- Molecular Formula: C11H12O3S
- Molecular Weight: 224.276
- Catalog: Chemical reagent Organic reagent Tosylate
- Create Date: 2018-05-18 08:00:00
- Modify Date: 2024-01-03 06:56:06
-
Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
| Name | but-3-ynyl 4-methylbenzenesulfonate |
|---|---|
| Synonyms |
3-Butyn-1-ol, 4-methylbenzenesulfonate
p-Toluenesulfonic Acid 3-Butynyl Ester homopropargyl alcohol tosylate 4-tosyloxy-1-butyne 3-butynyl p-tosylate but-3-yn-1-yl tosylate 3-Butyn-1-yl 4-methylbenzenesulfonate 3-Butynyl Tosylate but-3-yn-1-yl p-toluenesulfonate 3-(1-Butynyl)-4-toluenesulphonate But-3-yn-1-yl 4-methylbenzenesulfonate 3-Butynyl 4-methylbenzenesulfonate 3-Butynyl p-toluenesulfonate MFCD00041687 |
| Description | Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 352.0±25.0 °C at 760 mmHg |
| Molecular Formula | C11H12O3S |
| Molecular Weight | 224.276 |
| Flash Point | 166.7±23.2 °C |
| Exact Mass | 224.050720 |
| PSA | 51.75000 |
| LogP | 2.01 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.535 |
| Storage condition | Refrigerator (+4°C) |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S36/37/39-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2905290000 |
|
~99%
23418-85-1 |
| Literature: Fujiwara, Kenshu; Suzuki, Yuki; Koseki, Nao; Murata, Shun-Ichi; Murai, Akio; Kawai, Hidetoshi; Suzuki, Takanori Tetrahedron Letters, 2011 , vol. 52, # 43 p. 5589 - 5592 |
|
~94%
23418-85-1
Detail
|
| Literature: RIB-X PHARMACEUTICALS, INC. Patent: WO2004/29066 A2, 2004 ; Location in patent: Page/Page column 215 ; |
|
~91%
23418-85-1 |
| Literature: Zammit, Steven C.; Cox, Alison J.; Gow, Renae M.; Zhang, Yuan; Gilbert, Richard E.; Krum, Henry; Kelly, Darren J.; Williams, Spencer J. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 7003 - 7006 |
|
~%
23418-85-1 |
| Literature: Organic Letters, , vol. 11, # 20 p. 4548 - 4551 |
| Precursor 4 | |
|---|---|
| DownStream 10 | |
| HS Code | 2905290000 |
|---|---|
| Summary | 2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |