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PKN1/2-IN-1

Names

[ CAS No. ]:
942425-34-5

[ Name ]:
PKN1/2-IN-1

Biological Activity

[Description]:

PKN1/2-IN-1 is a potent, cell penetrant and selective PKN2 (PRK2) inhibitor (IC50=16 nM; Ki=8 nM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: 16 nM, Ki: 8 nM (PKN2)[1] IC50: 108 nM, Ki: 210 nM (PKN1)[1].


[References]

[1]. Scott F, et al. Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. Bioorg Med Chem Lett. 2022;60:128588.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H15N3O

[ Molecular Weight ]:
241.29

Related Compounds