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IDO1/2-IN-1

Names

[ CAS No. ]:
2310286-45-2

[ Name ]:
IDO1/2-IN-1

Biological Activity

[Description]:

IDO1/2-IN-1 (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)

[Target]

IDO1:28 nM (IC50)

IDO2:144 nM (IC50)


[References]

[1]. He X, et al. Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy. J Med Chem. 2021;64(24):17950-17968.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H18BrFN8O4

[ Molecular Weight ]:
485.27

Related Compounds