COX-2-IN-1

Names

[ Name ]:
COX-2-IN-1

[Synonym ]:
Benzenesulfonamide, 4-[5-(7-chloro-1H-indol-3-yl)-4,5-dihydro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-
4-[5-(7-Chloro-1H-indol-3-yl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide

Biological Activity

[Description]:

COX-2-IN-1 is potent and slective COX-2 inhibitor with an IC50 of 3.9 μM.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

COX-2:3.9 μM (IC50)

[In Vitro]

COX-2-IN-1(compound 5f) is an inhibitor of COX-1 and COX-2 with IC50s of >100 and 3.9 μM, respctively. Comparison of 5b and COX-2-IN-1 shows that smaller halogen atom at 5th position on the indole ring enhances COX-2 enzyme inhibition activity, whereas the presence of a larger bromine atom at 6th position of the ring improves the inhibitory activity (5d, 5e and 5h) of the compound[1].

[References]

[1]. Reddy MV, et al. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors. Bioorg Med Chem. 2008 Apr 1;16(7):3907-16.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
610.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₄ClF₃N₄O₂S

[ Molecular Weight ]:
442.843

[ Flash Point ]:
323.2±34.3 °C

[ Exact Mass ]:
442.047821

[ LogP ]:
3.17

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.682

Related Compounds

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