MDL 72527

[Description]:

MDL 72527 dihydrochloride is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 dihydrochloride shows a lysosomotropic effect. MDL 72527 dihydrochloride shows neuroprotective effects[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

polyamine oxidase (PAO)[1]

[In Vitro]

MDL 72527 dihydrochloride (300 µM; 24 h) 在 M14 WT 细胞中出现明显的形态学变化，出现大量溶酶体和大量细胞质空泡[2]。 Cell Cytotoxicity Assay[2] Cell Line: M14 cells Concentration: 300 µM Incubation Time: 24 h Result: Showed no significant effect on cell survival of melanoma cells.

[In Vivo]

MDL 72527 dihydrochloride (100 mg/kg; i.p.; once) 对暂时性局灶性脑缺血后的神经元细胞损伤具有神经保护作用[1]。 Animal Model: 250-300 g, Male spontaneously hypertensive rats (SHRs)[1] Dosage: 100 mg/kg Administration: I.p.; after the induction of ischemia Result: Significantly reduced meanarterial blood pressure, changed the brain edema formation from 85.7 ± 0.3 to 84.5 ± 0.9% in cortex and from 79.9 ± 1.7 to 78.4 ± 2.0% in subcortex (difference not significant), reduced ischemic injury volume by 22% in the cortex and 17% in the subcortex.

[References]

[1]. Doğan A, et al. Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J Neurochem. 1999 Feb;72(2):765-70.

[2]. Agostinelli E, et al. Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. Biochim Biophys Acta. 2006 Oct;1763(10):1040-50.

[ Boiling Point ]:
300.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₂₂Cl₂N₂

[ Molecular Weight ]:
265.22200

[ Flash Point ]:
159.2ºC

[ Exact Mass ]:
264.11600

[ PSA ]:
24.06000

[ LogP ]:
4.01380

[ Index of Refraction ]:
1.536

[ Storage condition ]:
2-8°C

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[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2921290000

[ HS Code ]: 2921290000

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

How important is the oxidative degradation of spermine?: minireview article.

Amino Acids 26(4) , 317-9, (2004)

Spermine is a constituent of most eucaryotic cells, however, it is not of vital importance for the vertebrate organism, as is demonstrated by the existence of transgenic (Gy) mice that lack spermine a...

Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells.

Amino Acids 42(2-3) , 619-26, (2012)

Polyamines spermidine and spermine are known to be required for mammalian cell proliferation and for embryonic development. Alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylas...

Synergism between apple procyanidins and lysosomotropic drugs: potential in chemoprevention.

Anticancer Res. 26(5A) , 3381-5, (2006)

Procyanidins are apple constituents with potential in colon cancer chemoprevention.Human colon cancer derived metastatic cells (SW620), growing under standardized conditions, were exposed to procyanid...

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