MDL 11,939

Names

[ Name ]:
MDL 11,939

[Synonym ]:
laminaritriose
Glemanserin

Biological Activity

[Description]:

Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively)[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter

[In Vivo]

Glemanserin (MDL11939) suppresses Morphine-induced increase in locomotor activity, behavioral sensitization and withdrawal symptoms in male mice[1].

[References]

[1]. Pehek EA, et al. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology. 2006;31(2):265-277.

Chemical & Physical Properties

[ Density]:
1.084g/cm3

[ Boiling Point ]:
434.2ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₅NO

[ Molecular Weight ]:
295.41900

[ Flash Point ]:
205.6ºC

[ Exact Mass ]:
295.19400

[ PSA ]:
23.47000

[ LogP ]:
3.61260

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H400

[ Precautionary Statements ]:
P273

[ RIDADR ]:
UN 3077 9 / PGIII

Articles

Selective remodeling of rabbit frontal cortex: relationship between 5-HT2A receptor density and associative learning.

Psychopharmacology 172(4) , 435-42, (2004)

Associative learning during classical trace eyeblink conditioning has been shown to be regulated by serotonin 5-HT(2A )receptors and to be critically dependent on the integrity of frontal cortex. Chro...

Effect of 5-HT2 receptor antagonists on a cranial nerve reflex in the rabbit: evidence for inverse agonism.

Psychopharmacology 141 , 162, (1999)

This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) ...

Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors.

Psychopharmacology 201(1) , 55-66, (2008)

The hallucinogenic tea known as ayahuasca is made from a combination of psychoactive plants that contribute the active components N,N-dimethyltryptamine (DMT) and 5-methoxy-DMT (5-MeO-DMT), as well as...