DFMTI

Names

[ Name ]:
DFMTI

[Synonym ]:
1H-Isoindol-1-one, 5-[1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-2-(1-methylethyl)-
5-[1-(2,4-Difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2-isopropyl-1-isoindolinone

Biological Activity

[Description]:

DFMTI can completely block the rmGlu1 L757V glutamate response.In vitro: DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade.In vivo: DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Cho HP et al. A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors. ACS Chem Neurosci. 2014 Jul 16;5(7):597-610.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
545.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₈F₂N₄O

[ Molecular Weight ]:
368.380

[ Flash Point ]:
283.5±32.9 °C

[ Exact Mass ]:
368.144867

[ LogP ]:
3.00

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.645

Related Compounds

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