Moexipril HCl

Names

[ Name ]:
Moexipril HCl

[Synonym ]:
Uniretic
Univasc
SPM 925
Moexipril HCl
Moexipril HCL
MOEXIPRIL HYDROCHLORIDE
CI-925
UNII-Q1UMG3UH45
Moexipril (hydrochloride)

Biological Activity

[Description]:

Moexipril HCl is a potent orally active non-sulfhydryl angiotensin converting enzyme(ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure. Target: ACEMoexipril is a long-acting ACE inhibitor suitable for once-daily administration, and like some ACE inhibitors, moexipril is a prodrug and needs to be hydrolyzed in the liver into its active carboxylic metabolite, moexiprilat, to become effective [1]. Upon oral administration of moexipril (10 mg/kg/day) to spontaneously hypertensive rats, plasma angiotensin II concentration decreased to undetectable levels, plasma ACE activity was inhibited by 98% and plasma angiotensin I concentration increased 8.6-fold 1 h after dosing. At 24 h, plasma angiotensin I and angiotensin II concentrations had returned to pretreatment levels, whereas plasma ACE activity was still inhibited by 56%. Four-week oral administration of moexipril (0.1-30 mg/kg/day) to spontaneously hypertensive rats lowered blood pressure and differentially inhibited ACE activity in plasma, lung, aorta, heart and kidney in a dose-dependent fashion [2, 3].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

Research Areas >> Cardiovascular Disease

[References]

[1]. Chrysant, S.G. and G.S. Chrysant, Pharmacological and clinical profile of moexipril: a concise review. J Clin Pharmacol, 2004. 44(8): p. 827-36.

[2]. Edling, O., et al., Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril. J Pharmacol Exp Ther, 1995. 275(2): p. 854-63.

[3]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
709.3ºC at 760 mmHg

[ Melting Point ]:
141-161ºC

[ Molecular Formula ]:
C₂₇H₃₅ClN₂O₇

[ Molecular Weight ]:
535.03

[ Flash Point ]:
382.8ºC

[ PSA ]:
114.40000

[ LogP ]:
3.71510

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H400

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
N:Dangerous for the environment

[ Risk Phrases ]:
R50

[ Safety Phrases ]:
60

[ RIDADR ]:
UN 3077

[ RTECS ]:
NW7174500

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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