Moexipril HCl structure
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Common Name | Moexipril HCl | ||
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CAS Number | 82586-52-5 | Molecular Weight | 535.03 | |
Density | N/A | Boiling Point | 709.3ºC at 760 mmHg | |
Molecular Formula | C27H35ClN2O7 | Melting Point | 141-161ºC | |
MSDS | Chinese USA | Flash Point | 382.8ºC | |
Symbol |
GHS09 |
Signal Word | Warning |
Use of Moexipril HClMoexipril HCl is a potent orally active non-sulfhydryl angiotensin converting enzyme(ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure. Target: ACEMoexipril is a long-acting ACE inhibitor suitable for once-daily administration, and like some ACE inhibitors, moexipril is a prodrug and needs to be hydrolyzed in the liver into its active carboxylic metabolite, moexiprilat, to become effective [1]. Upon oral administration of moexipril (10 mg/kg/day) to spontaneously hypertensive rats, plasma angiotensin II concentration decreased to undetectable levels, plasma ACE activity was inhibited by 98% and plasma angiotensin I concentration increased 8.6-fold 1 h after dosing. At 24 h, plasma angiotensin I and angiotensin II concentrations had returned to pretreatment levels, whereas plasma ACE activity was still inhibited by 56%. Four-week oral administration of moexipril (0.1-30 mg/kg/day) to spontaneously hypertensive rats lowered blood pressure and differentially inhibited ACE activity in plasma, lung, aorta, heart and kidney in a dose-dependent fashion [2, 3]. |
Name | (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid,hydrochloride |
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Synonym | More Synonyms |
Description | Moexipril HCl is a potent orally active non-sulfhydryl angiotensin converting enzyme(ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure. Target: ACEMoexipril is a long-acting ACE inhibitor suitable for once-daily administration, and like some ACE inhibitors, moexipril is a prodrug and needs to be hydrolyzed in the liver into its active carboxylic metabolite, moexiprilat, to become effective [1]. Upon oral administration of moexipril (10 mg/kg/day) to spontaneously hypertensive rats, plasma angiotensin II concentration decreased to undetectable levels, plasma ACE activity was inhibited by 98% and plasma angiotensin I concentration increased 8.6-fold 1 h after dosing. At 24 h, plasma angiotensin I and angiotensin II concentrations had returned to pretreatment levels, whereas plasma ACE activity was still inhibited by 56%. Four-week oral administration of moexipril (0.1-30 mg/kg/day) to spontaneously hypertensive rats lowered blood pressure and differentially inhibited ACE activity in plasma, lung, aorta, heart and kidney in a dose-dependent fashion [2, 3]. |
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Related Catalog | |
References |
Boiling Point | 709.3ºC at 760 mmHg |
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Melting Point | 141-161ºC |
Molecular Formula | C27H35ClN2O7 |
Molecular Weight | 535.03 |
Flash Point | 382.8ºC |
PSA | 114.40000 |
LogP | 3.71510 |
Storage condition | 2-8°C |
~88% Moexipril HCl CAS#:82586-52-5 |
Literature: Klutchko; Blankley; Fleming; Hinkley; Werner; Nordin; Holmes; Hoefle; Cohen; Essenburg Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1953 - 1961 |
Precursor 1 | |
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DownStream 2 | |
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Uniretic |
Univasc |
SPM 925 |
Moexipril HCl |
Moexipril HCL |
MOEXIPRIL HYDROCHLORIDE |
CI-925 |
UNII-Q1UMG3UH45 |
Moexipril (hydrochloride) |